Constitutive expression of IκBζ promotes tumor growth and immunotherapy resistance in melanoma
Antonia Kolb, Ana-Marija Kulis-Mandic, Matthias Klein, Anna Stastny, Maximilian Haist, Vanessa Votteler, Beate Weidenthaler‐Barth, Tobias W. Sinnberg, Antje Sucker, Gabriele Allies, Lea Jessica Albrecht, Alpaslan Tasdogan, Andrea Tuettenberg, Matthias M. Gaida, Carsten Deppermann, , Daniela Kramer
This study shows that constitutive IκBζ expression in melanoma promotes tumor growth and immunotherapy resistance by suppressing cytokine production and immune cell recruitment.
Nature Communications · Jun 25, 2025Peer-reviewedCancer Biology