The acidic N-terminus of HHARI and neddylation are essential for the activation and maintenance of RIG-I-mediated type I interferon response
Ioanna Kontra, Harry C. Ward, Faith Vinluan, Rachel Lau, Anna Surace, Vinothini Rajeeve, Pedro Cutillas, Benjamin Stieglitz, Myles Lewis
This study identifies the acidic N-terminus and neddylation of HHARI as essential for RIG-I activation and type I interferon signaling.
bioRxiv · Feb 1, 2025 · PreprintImmunology