Author

Rachel Lau

Queen Mary University of LondonORCID 0000-0002-8330-8048Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Rachel Lau1 paper · Public Health Ontario

Biology Disciplines

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Immunology· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Myles LewisiD· 4 shared Costantino PitzalisiD· 2 shared Accelerating Medicines Partnership RA/SLE Network· 1 shared Accelerating Medicines Partnership: Autoimmune and Immune-Mediated Diseases Network (AMP-AIM)· 1 shared Adam J. SeidliD· 1 shared Adam P. CroftiD· 1 shared Alexa B. R. McIntyreiD· 1 shared Almke BaderiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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4 shared papersImmunology

Myles LewisORCID

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4 papers

Recent·Most cited

cellGeometry: ultra-fast single-cell deconvolution of bulk RNA-Seq using a geometric solution

Rachel Lau, Cankut Çubuk, Athina Spiliopoulou, Pedro Martínez-Paz, Anna E. A. Surace, Liliane Fossati‐Jimack, Soumya Raychaudhuri, Costantino Pitzalis, Myles Lewis

cellGeometry deconvolutes bulk RNA-Seq using geometric methods, offering faster and more accurate results than existing approaches.

Nature Communications · Jul 23, 2026Peer-reviewedBioinformatics

Orphan GPR84 facilitates uropod de-adhesion to terminate leukocyte diapedesis during inflammation

Clare H Latta, Terrence M Trinca, Francesca Robertson, Rachel Lau, Anna Barkaway, Loïc Rolas, Matthew C.H.M. Golding, Paul R. C. Imbert, H. Wang, Almke Bader, Liam Hill, Lorna R. Hodgson, Barbara Walzog, Myles Lewis, Mathieu-Benoı̂t Voisin, , Helen Weavers

This study identifies GPR84 as a regulator of immune cell extravasation by enabling uropod de-adhesion during inflammation, showing its role in terminating leukocyte migration.

bioRxiv · Feb 2, 2026 · PreprintImmunology

Spatial patterning of fibroblast TGFβ signaling underlies treatment resistance in rheumatoid arthritis

Kartik Bhamidipati, Alexa B. R. McIntyre, Shideh Kazerounian, Ce Gao, Soon Wei Wong, Miles Tran, Sean A. Prell, Rachel Lau, Vikram Khedgikar, Christopher Altmann, Annabelle Small, Roopa Madhu, Sonia Presti, Ksenia S. Anufrieva, PHILIP E. BLAZAR, , Kevin Wei

Perivascular COMPhi fibrogenic fibroblasts expand in treatment-refractory rheumatoid arthritis synovium, where endothelial Notch signaling patterns fibroblast TGF-beta sensitivity via TGFBR3 regulation and persists despite post-treatment immune cell depletion.

Nature Immunology · Jan 15, 2026Peer-reviewedImmunology✦ In-depth digest

The acidic N-terminus of HHARI and neddylation are essential for the activation and maintenance of RIG-I-mediated type I interferon response

Ioanna Kontra, Harry C. Ward, Faith Vinluan, Rachel Lau, Anna Surace, Vinothini Rajeeve, Pedro Cutillas, Benjamin Stieglitz, Myles Lewis

This study identifies the acidic N-terminus and neddylation of HHARI as essential for RIG-I activation and type I interferon signaling.

bioRxiv · Feb 1, 2025 · PreprintImmunology