Vinothini Rajeeve

This study shows lung cancer stem cells adapt to the brain microenvironment through neuro-mimetic reprogramming and epigenetic changes, enabling metastasis.

This study shows Greatwall kinase regulates AML cell division through a non-canonical pathway distinct from its role in solid tumors.

This study identifies two β3-integrin-dependent metabolic states in pericytes and shows their impact on tumour-stromal metabolic interactions in breast cancer.

This study identifies DUSP6 as a novel effector of ALK signaling in neuroblastoma, showing it enhances ALK-driven proliferation and reduces sensitivity to ALK inhibitors.

This study shows LIMD1 is essential for effective miRNA targeting and repression by AGO2, revealing its role in expanding miRNA regulatory capacity beyond conserved targets.

The paper identifies a nine-marker signature of lapatinib resistance in HER2-positive breast cancer using integrative multi-omics analysis, revealing novel biomarkers and chromatin dynamics associated with drug resistance.

This study identifies the acidic N-terminus and neddylation of HHARI as essential for RIG-I activation and type I interferon signaling.

This study identifies RAS-PI3K signaling as a key regulator of myofibroblastic CAF identity and matrix competence in lung cancer, showing its role in restraining immunomodulatory stromal programs.

The paper identifies two distinct subgroups of KMT2A-rearranged AML using phosphoproteomics and shows different drug response profiles.