MORC-1 is a key component of the C. elegans CSR-1 germline gene licensing mechanism
Jessica A. Kirshner, Colette Lafontaine Picard, Natasha E. Weiser, Nicita Mehta, Suhua Feng, Victoria N Murphy, Anna Vakhnovetsky, Amelia F. Alessi, Connie Xiao, Kai Inoki, Sonia El Mouridi, Christian Frøkjær‐Jensen, Steven E. Jacobsen, John K. Kim
The paper shows MORC-1 overexpression in csr-1 mutants drives gene downregulation by altering chromatin states, revealing its role in CSR-1-mediated gene licensing.
bioRxiv · Oct 2, 2024 · PreprintMolecular Biology