Colette Lafontaine Picard

J-domain proteins bridge the PKL and ATRX complex to transcription factors to fine-tune gene expression via H3.3 deposition

The paper identifies J-domain proteins as mediators of PKL recruitment to gene promoters, enabling H3.3 deposition and influencing gene expression through interactions with transcription factors and ATRX.

An antagonistic epigenetic mechanism regulating gene expression in pollen revealed through single-nucleus multiomics

The paper reveals an antagonistic epigenetic mechanism in Arabidopsis pollen where MBD5/6 repress methylated loci while MBD7 promotes demethylation and transcriptional activation.

MORC-1 is a key component of the C. elegans CSR-1 germline gene licensing mechanism

The paper shows MORC-1 overexpression in csr-1 mutants drives gene downregulation by altering chromatin states, revealing its role in CSR-1-mediated gene licensing.

Enhancers associated with unstable RNAs are rare in plants

The paper identifies that unstable transcripts are rare in plants and often originate from promoters, challenging the use of genome annotations to infer enhancers.

Single-nucleus RNA-seq reveals that MBD5, MBD6, and SILENZIO maintain silencing during epigenetic reprogramming in pollen

The paper uses single-nucleus RNA-seq to show that MBD5, MBD6, and SILENZIO are critical for TE silencing in pollen vegetative cells during epigenetic reprogramming.

A dose-sensitive OGT-TET3 complex is necessary for normal Xist RNA distribution and function

The paper identifies an OGT-TET3 complex that regulates 5mC and 5hmC levels and XCI in female mouse embryonic stem cells.

The histone variant H2A.W and linker histone H1 co-regulate heterochromatin accessibility and DNA methylation

This study shows that H2A.W and H1 co-regulate heterochromatin accessibility and DNA methylation in flowering plants by modulating H1 deposition and non-CG methylation.