A bipartite element with allele-specific functions safeguards DNA methylation imprints at the Dlk1-Dio3 locus
Boaz E. Aronson, Laurianne Scourzic, Veevek Shah, Emily Swanzey, Andreas Kloetgen, Alexander Polyzos, Abhishek Sinha, Annabel Azziz, Inbal Caspi, Jiexi Li, Bobbie Pelham‐Webb, Rachel A. Glenn, Thomas Vierbuchen, Hynek Wichterle, Aristotelis Tsirigos, , Effie Apostolou
The paper identifies a bipartite imprinting control region at the Dlk1-Dio3 locus that maintains imprint stability through allele-specific regulation of DNA methylation and chromatin structure.
Developmental Cell · Oct 27, 2021Peer-reviewedDevelopmental Biology