Small-molecule inhibitor of C-terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells
Céline David, Yadong Sun, Vitalij Woloschin, Melina Vogt, Niklas Dienstbier, Annabelle Friedrich, Karina Stephanie Krings, David Schlütermann, Lena Berning, Beate Lungerich, Seda Akgün, María José Mendiburo, Christoph G. W. Gertzen, Arndt Borkhardt, Sebastian Wesselborg, , Björn Stork
This paper introduces a C-terminal HSP90 dimerization inhibitor, VWK147, which induces cell death in cisplatin-resistant cancer cells and synergizes with mTOR inhibition to enhance therapeutic efficacy.
Cell Death and Disease · Dec 23, 2025Peer-reviewedCell Biology