Author

Sebastian Wesselborg

Düsseldorf University HospitalORCID 0000-0002-5236-942XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:development & morphogenesis· 1

Frequent Co-Authors

Björn StorkiD· 2 shared Karina Stephanie KringsiD· 2 shared María José MendiburoiD· 2 shared Seda Akgün· 2 shared Alessandro PrigioneiD· 1 shared Annabelle Friedrich· 1 shared Annika ZinkiD· 1 shared Arndt BorkhardtiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Björn StorkORCID

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2 papers

Recent·Most cited

Canonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide.

Seda Akgün, Padmashri Naren, Thomas Lenz, Annika Zink, Karina Stephanie Krings, Sebastian Wesselborg, María José Mendiburo, Alessandro Prigione, Kai Stühler, Björn Stork

This study shows that canonical autophagy remains inactive in iPSCs and NPCs under DNA damage, despite a functional autophagy machinery and responsive DNA damage response.

Scientific Reports · Jun 8, 2026Peer-reviewedCell Biology

Small-molecule inhibitor of C-terminal HSP90 dimerization modulates autophagy and functions synergistically with mTOR inhibition to kill cisplatin-resistant cancer cells

Céline David, Yadong Sun, Vitalij Woloschin, Melina Vogt, Niklas Dienstbier, Annabelle Friedrich, Karina Stephanie Krings, David Schlütermann, Lena Berning, Beate Lungerich, Seda Akgün, María José Mendiburo, Christoph G. W. Gertzen, Arndt Borkhardt, Sebastian Wesselborg, , Björn Stork

This paper introduces a C-terminal HSP90 dimerization inhibitor, VWK147, which induces cell death in cisplatin-resistant cancer cells and synergizes with mTOR inhibition to enhance therapeutic efficacy.

Cell Death and Disease · Dec 23, 2025Peer-reviewedCell Biology