Björn Stork

This study shows that canonical autophagy remains inactive in iPSCs and NPCs under DNA damage, despite a functional autophagy machinery and responsive DNA damage response.

This paper introduces a C-terminal HSP90 dimerization inhibitor, VWK147, which induces cell death in cisplatin-resistant cancer cells and synergizes with mTOR inhibition to enhance therapeutic efficacy.

This study shows SIRT4 promotes autophagy by modulating ULK1 phosphorylation, independent of HDAC6 and OPA1, and identifies its role in early autophagy initiation.

The paper identifies S210 phosphorylation of Lamin B1 by ULK1 and Aurora A/PLK1 as critical for spindle function during mitosis.

This study identifies Mfn2's role in promoting NCLX-mediated Ca2+ release from mitochondria, linking mitochondrial ROS to mitophagy via Ca2+ signaling.