Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment
Shawn A. Hallett, Wanida Ono, Yuki Matsushita, Naoko Sakagami, Koji Mizuhashi, Nicha Tokavanich, Mizuki Nagata, Annabelle Zhou, Takao Hirai, Henry M. Kronenberg, Noriaki Ono
The paper identifies a Wnt-inhibitory environment maintaining resting zone chondrocytes and shows that Wnt activation disrupts their differentiation into columnar chondrocytes.
eLife · Jul 26, 2021Peer-reviewedDevelopmental Biology