Noriaki Ono

CytoSignal Detects Locations and Dynamics of Ligand-Receptor Signaling at Cellular Resolution from Spatial Transcriptomic Data

CytoSignal detects and quantifies ligand-receptor signaling interactions at cellular resolution from spatial transcriptomic data, enabling spatial gradient analysis and temporal dynamics prediction.

CytoSimplex: Visualizing Single-cell Fates and Transitions on a Simplex

CytoSimplex visualizes cell differentiation trajectories using simplex geometry to represent cell fate commitment and potential in 2D and 3D plots.

Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases

This study shows that deleting SIK2/SIK3 in alveolar bone reduces bone formation and mass by impairing osteoblast maturation, unlike in long bones where it increases bone formation and mass.

Growth plate resting zone chondrocytes acquire transient clonal competency upon Hedgehog activation and efficiently transform into trabecular bone osteoblasts

This study shows that Hedgehog activation in resting zone chondrocytes converts them into osteoblasts through clonal expansion and migration.

Control of Craniofacial Development by the Collagen Receptor, Discoidin Domain Receptor 2

This study investigates the role of DDR2 in craniofacial development using Ddr2-deficient mice, revealing defects in bone growth, suture formation, and chondrogenesis.

Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

The paper identifies a Wnt-inhibitory environment maintaining resting zone chondrocytes and shows that Wnt activation disrupts their differentiation into columnar chondrocytes.

Notch effector Hes1 marks an early perichondrial population of skeletal progenitor cells at the onset of endochondral bone development

The paper identifies Hes1 as a marker for early perichondrial skeletal progenitor cells using single-cell RNA-seq and lineage tracing in endochondral bone development.