Wanida Ono

Control of alveolar bone development, homeostasis, and socket healing by salt inducible kinases

This study shows that deleting SIK2/SIK3 in alveolar bone reduces bone formation and mass by impairing osteoblast maturation, unlike in long bones where it increases bone formation and mass.

Growth plate resting zone chondrocytes acquire transient clonal competency upon Hedgehog activation and efficiently transform into trabecular bone osteoblasts

This study shows that Hedgehog activation in resting zone chondrocytes converts them into osteoblasts through clonal expansion and migration.

Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

The paper identifies a Wnt-inhibitory environment maintaining resting zone chondrocytes and shows that Wnt activation disrupts their differentiation into columnar chondrocytes.

Notch effector Hes1 marks an early perichondrial population of skeletal progenitor cells at the onset of endochondral bone development

The paper identifies Hes1 as a marker for early perichondrial skeletal progenitor cells using single-cell RNA-seq and lineage tracing in endochondral bone development.