Author

Yuki Matsushita

University of MichiganORCID 0000-0001-9577-3249Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 3

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Approach:experimental assay· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Noriaki OnoiD· 3 shared Wanida OnoiD· 3 shared Koji Mizuhashi· 2 shared Mizuki NagataiD· 2 shared Naoko Sakagami· 2 shared Annabelle Zhou· 1 shared Henry M. KronenbergiD· 1 shared Joshua D. WelchiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersDevelopmental Biology

Noriaki OnoORCID

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3 papers

Recent·Most cited

Growth plate resting zone chondrocytes acquire transient clonal competency upon Hedgehog activation and efficiently transform into trabecular bone osteoblasts

Shion Orikasa, Yuki Matsushita, Michael Fogge, Koji Mizuhashi, Naoko Sakagami, Wanida Ono, Noriaki Ono

This study shows that Hedgehog activation in resting zone chondrocytes converts them into osteoblasts through clonal expansion and migration.

bioRxiv · May 31, 2023 · PreprintDevelopmental Biology

Chondrocytes in the resting zone of the growth plate are maintained in a Wnt-inhibitory environment

Shawn A. Hallett, Wanida Ono, Yuki Matsushita, Naoko Sakagami, Koji Mizuhashi, Nicha Tokavanich, Mizuki Nagata, Annabelle Zhou, Takao Hirai, Henry M. Kronenberg, Noriaki Ono

The paper identifies a Wnt-inhibitory environment maintaining resting zone chondrocytes and shows that Wnt activation disrupts their differentiation into columnar chondrocytes.

eLife · Jul 26, 2021Peer-reviewedDevelopmental Biology

Notch effector Hes1 marks an early perichondrial population of skeletal progenitor cells at the onset of endochondral bone development

Yuki Matsushita, Mizuki Nagata, Joshua D. Welch, Sunny Y. Wong, Wanida Ono, Noriaki Ono

The paper identifies Hes1 as a marker for early perichondrial skeletal progenitor cells using single-cell RNA-seq and lineage tracing in endochondral bone development.

bioRxiv · Mar 13, 2020 · PreprintDevelopmental Biology