Salvatore Valvo

Synaptic synergy of T cell receptor and interleukin 2 receptor in CD8+ T cells

The paper shows that TCR and IL2 receptor signaling synergize at the immunological synapse of CD8+ T cells, enhancing T-T synapse formation and function.

Human CD8-iTreg are potent GVHD suppressors and tumoricidal effectors by release of Granzyme-K+ Supramolecular Attack Particles

This study identifies CD8-iTreg as potent anti-tumor effectors and GVHD suppressors through Granzyme-K+ supramolecular attack particles.

PD-1 remodels SHP2 dynamics and drives the non-catalytic inhibition of T cell activation

This study reveals that PD-1 remodels SHP2 dynamics to inhibit T cell activation through a non-catalytic mechanism, independent of its phosphatase activity.

Immune receptor LILRB1 mediates cis-signalling which is targeted by RIFINs of the malaria parasite

The paper shows RIFINs of Plasmodium falciparum bind LILRB1 in different conformations, triggering inhibitory signaling either in trans or cis to suppress immune responses.

CD4⁺ T cells confer transplantable rejuvenation via Rivers of telomeres

The paper shows CD4 T cells release telomere-rich vesicles called Rivers, which rejuvenate senescent tissues and extend lifespan in mice.

Isolation of functional supramolecular attack particles (SMAPs)

This paper develops a method to isolate and characterize SMAPs from NK-92 cells, showing their cytotoxic activity against tumor cells in vitro and in vivo.

Mixed-mobility supported lipid bilayers reveal the modulatory role ofimmobilized ICAM1 on T cell activation, effector functions and immune synapse organization

Glycogen synthase kinase-3 is essential for Treg development and function

This study shows that GSK3 is essential for Treg development and function, as its loss leads to metabolic changes, pro-inflammatory gene expression, and enhanced anti-tumoral immunity.

Thrombospondins 1 and 4 undergo coordinated transport to multicore cytotoxic granules to regulate SMAP biogenesis and function in CTL-mediatedcytotoxicity

This study shows TSP-4 is required for TSP-1 association with lytic granules and SMAP-mediated cytotoxicity in CTLs, and its expression is suppressed in CLL cell supernatants.

STAT3 phosphorylation in the rheumatoid arthritis immunological synapse

This study identifies a JAK-independent mechanism of STAT3 activation in RA through TCR-dependent phosphorylation at the immunological synapse, suggesting a new therapeutic target.

A resource for extracellular vesicles from activated CD4 T cells that relay pro-inflammatory signals

This study characterizes extracellular vesicles from activated CD4 T cells and shows their pro-inflammatory effects on antigen-presenting cells, providing a resource for EV-based therapeutic development.