Acylation of the RTX Toxin MbxA stimulates host membrane disruption through a specific interaction with cholesterol
Feby Mariam Chacko, Sarah Michelle Ganz, Anne Pfitzer-Bilsing, Sebastian Hänsch, Philipp Westhoff, Stefanie Weidtkamp‐Peters, Sander H. J. Smits, Marten Exterkate, Lutz Schmitt
This study investigates how acylation of the RTX toxin MbxA enhances membrane disruption by interacting with cholesterol, showing acylation promotes pore formation but not initial membrane binding.
Biochimica et Biophysica Acta (BBA) - Biomembranes · Nov 27, 2025Peer-reviewedBiochemistry