Lutz Schmitt

This study reports the cryo-EM structure of Pdr5, showing ergosterol binding and its effect on transporter activity, with implications for fungal drug resistance.

This study shows Ubp3 dynamically regulates mitochondrial ubiquitination during mitophagy, revealing its role in ubiquitin storage and release as a stress response mechanism.

This study shows that the catalytic activity of Ubp3, a yeast deubiquitinase, is independent of its interaction partner Bre5, challenging the current model of Bre5-dependent activation.

This study investigates how acylation of the RTX toxin MbxA enhances membrane disruption by interacting with cholesterol, showing acylation promotes pore formation but not initial membrane binding.

The paper presents the first complete structural model of the HlyA T1SS using cryo-EM and SAXS, revealing CLD domain dynamics and toxin binding mechanisms.

This study investigates how reconstituted Pdr5 transporter moves Rhodamine 6G across a lipid bilayer using ATP, showing active transport of the cation.