SCN1A haploinsufficiency disrupts neural progenitor networks and accelerates neurogenesis in human Dravet syndrome forebrain assembloids
Deepika Dogra, Harmony Fong, Sinan Zhang, Takuma Sumi, Nicole L. Rosin, Nicolás Collao, Marissa Gordon, Anneke Korver, Cezar Gavrilovici, Duncan Noble, Segundo Jose Guzman, Leili Rohani, Derrick E. Rancourt, Jeff A. Biernaskie, Julia Jacobs-LeVan, , Deborah Marie Kurrasch
This study shows that SCN1A haploinsufficiency disrupts neural progenitor networks and accelerates neurogenesis in human Dravet syndrome forebrain assembloids, leading to altered corticogenesis and circuit hyperexcitability.
bioRxiv · Oct 16, 2026 · PreprintNeuroscience