Jeff A. Biernaskie

SCN1A haploinsufficiency disrupts neural progenitor networks and accelerates neurogenesis in human Dravet syndrome forebrain assembloids

This study shows that SCN1A haploinsufficiency disrupts neural progenitor networks and accelerates neurogenesis in human Dravet syndrome forebrain assembloids, leading to altered corticogenesis and circuit hyperexcitability.

Spinal cord Ca2+ imaging reveals glial-driven central sensitization in post-traumatic osteoarthritis

The paper develops a Ca2+ imaging pipeline to analyze spinal cord activity in pain models, identifying a glial-driven signature in post-traumatic osteoarthritis.

Cilia beating of ependymal cells regulates adult neural stem cell quiescence via mechanical forces mediated by PKD1/2-TRPM3

The paper shows that ependymal cell cilia beating regulates neural stem cell quiescence through mechanical forces involving PKD1/2 and TRPM3.

B Cell-Induced Lymph Node Stromal Remodeling Compromises Neutrophil Response to Secondary Staphylococcus aureus Infection

This study shows that B cell-induced lymph node stromal remodeling impairs neutrophil response to secondary Staphylococcus aureus infection by disrupting the FRC-conduit network.

Etv5 is not required for Schwann cell development but is required to regulate the Schwann cell response to peripheral nerve injury

This study shows Etv5 is not needed for Schwann cell development but is essential for regulating their response to peripheral nerve injury.

The gut microbiota is a determinant of sexual dimorphism in ALS-linked TDP43 mice

This study shows that the gut microbiota influences sexual dimorphism in ALS-linked TDP43 mice by affecting disease onset and severity, independent of sex hormones.

The Diversified Astrocyte Developmental Programs are Modulated by Primary Ciliary Signaling

This study shows primary cilia modulate astrocyte diversity and function through Shh signaling and intracellular balance, affecting neuronal development and behavior.

A single-cell transcriptomics atlas for the parasitic nematode Heligmosomoides bakeri: Extrapolating model organism information to non-model systems

This paper constructs a single-cell transcriptomics atlas for the parasitic nematode Heligmosomoides bakeri using orthologs from C. elegans to compare cell types and biological processes.

Single-cell analysis reveals distinct fibroblast plasticity during tenocyte regeneration in zebrafish

The paper uses single-cell RNA sequencing to identify fibroblast subtypes in zebrafish and shows that perivascular/interstitial fibroblasts regenerate tenocytes via Hedgehog signaling.

Cystatin C is glucocorticoid-responsive, directs recruitment of Trem2+ macrophages and predicts failure of cancer immunotherapy

This study identifies Cystatin C as a glucocorticoid-responsive factor that recruits Trem2+ macrophages and predicts immunotherapy failure in cancer.

The development of brain pericytes requires expression of the transcription factor nkx3.1 in intermediate precursors

This study identifies nkx3.1-expressing precursors in zebrafish that differentiate into brain pericytes and shows their regulation by cxcl12b-Cxcr4 signaling.

Proneural genes define ground state rules to regulate neurogenic patterning and cortical folding

The paper shows Neurog2 and Ascl1 genes regulate cortical progenitor differentiation and folding through Notch signaling in lissencephalic brains.