Takuma Sumi

This study shows that SCN1A haploinsufficiency disrupts neural progenitor networks and accelerates neurogenesis in human Dravet syndrome forebrain assembloids, leading to altered corticogenesis and circuit hyperexcitability.

This study uses microfluidic platforms to investigate how damage to hub or peripheral connections in modular neuronal networks affects recovery, finding that hub damage leads to delayed recovery through alternative pathway formation.

This paper develops a closed-loop biological neural network system that learns and generates temporal patterns through feedback control, demonstrating adaptability and reduced synchronization.

This paper models how modular structure and spike-timing-dependent plasticity influence recovery in damaged neuronal networks.