Segundo Jose Guzman

This study shows that SCN1A haploinsufficiency disrupts neural progenitor networks and accelerates neurogenesis in human Dravet syndrome forebrain assembloids, leading to altered corticogenesis and circuit hyperexcitability.

This paper uses cerebral organoids to model Tuberous Sclerosis Complex and identifies mechanisms of neural activity changes in epileptogenesis, showing potential for drug testing.

This study develops a full-scale dentate gyrus network model to show that PV+ interneurons enable efficient pattern separation through lateral inhibition and fast signaling.