Thiazole substitution of a labile amide bond - a new option towards stable pantothenamide-mimics
Xiangning Liu, Annica Chu, Mina Nekouei, Chunling Blue Lan, Karine Auclair, Kevin J. Saliba
This study develops pantothenamide-mimics with thiazole rings to overcome degradation by pantetheinase, showing potent antiplasmodial activity and enzyme selectivity.
bioRxiv · Feb 25, 2025 · PreprintPharmacology & Toxicology