NeuroscienceGliaPeer-reviewed
Astrocytic uptake of posttranslationally modified amyloid-β leads to endolysosomal system disruption and induction of pro-inflammatory signaling
Sarah Wirth, Annika Schlößer, Antonia Beiersdorfer…·Katarzyna M. Grochowska
This study shows that astrocytic uptake of modified Aβ3(pE)-42 disrupts the endolysosomal system, leading to inflammation and synapse loss in Alzheimer's disease.
12 citations