Screening of a kinase inhibitor library in human Huntington disease iPSC derived striatal precursor neurons reveals a neuroprotective effect of PKC alpha and PKC beta1 inhibition
Mali Jiang, Tianze Shi, Ritika Miryala, Matthew Rodriguez, Ronald S. Wang, Rashi Sultania, Lauren C. Guttman, Julia Johnston, Louisa Mulligan, Yushan Li, Anning Cui, Karim Belkas, Yuxuan Xue, Yuna Um, Amy Yuan, , Christopher A. Ross
The paper screens a kinase inhibitor library in HD iPSC-derived neurons to identify PKC alpha and beta1 inhibition as neuroprotective against mutant huntingtin toxicity.
bioRxiv · Sep 18, 2025 · PreprintNeuroscience