Christopher A. Ross

This study optimizes IVF procedures in common marmosets by identifying factors like progesterone levels and stimulation duration that improve embryo development and implantation rates.

The paper optimizes sperm processing and cryopreservation methods in common marmosets to improve motility and reduce DNA fragmentation for IVF applications.

This study introduces an ultra-rare AKAP11 protein-truncating variant in mice, showing it causes anxiety- and depression-like behaviors and disrupts PKA signaling.

The paper introduces a computer vision framework to analyze fine motor behaviors in HD mice, identifying disease-specific motor signatures and a scoring system to assess therapeutic effects.

The paper identifies HTT interactors involved in DNA damage response, chromatin remodeling, and RNA processing pathways, revealing HTT's role in double strand break repair and its interaction with DNA-PKcs and RNA binding proteins.

The paper screens a kinase inhibitor library in HD iPSC-derived neurons to identify PKC alpha and beta1 inhibition as neuroprotective against mutant huntingtin toxicity.

This study shows that expanded ATXN2 transcripts are toxic and disrupt rRNA processing in SCA2, similar to expanded HTT transcripts in HD, suggesting a shared mechanism in repeat expansion diseases.

This study shows that HTT silencing in premanifest HD mice delays disease onset and slows progression, using CBVa as a noninvasive biomarker.

This study identifies TBK1 as a kinase that phosphorylates mutant huntingtin, reduces its aggregation and toxicity in multiple HD models.