Author

Chloe D. Holland

Johns Hopkins University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Christopher A. RossiD· 2 shared Mali JiangiD· 2 shared Matthew RodrigueziD· 2 shared Tamara RatovitskiiD· 2 shared Tianze ShiiD· 2 shared Alexey V. Shevelkin· 1 shared Amy Yuan· 1 shared Anning Cui· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Christopher A. RossORCID

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2 papers

Recent·Most cited

Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathways

Tamara Ratovitski, Chloe D. Holland, Robert N. O’Meally, Alexey V. Shevelkin, Siddhi V Kamath, Tianze Shi, Matthew Rodriguez, Robert Norman Cole, Mali Jiang, Christopher A. Ross

The paper identifies HTT interactors involved in DNA damage response, chromatin remodeling, and RNA processing pathways, revealing HTT's role in double strand break repair and its interaction with DNA-PKcs and RNA binding proteins.

Life Science Alliance · Mar 18, 2026Peer-reviewedNeuroscience

Screening of a kinase inhibitor library in human Huntington disease iPSC derived striatal precursor neurons reveals a neuroprotective effect of PKC alpha and PKC beta1 inhibition

Mali Jiang, Tianze Shi, Ritika Miryala, Matthew Rodriguez, Ronald S. Wang, Rashi Sultania, Lauren C. Guttman, Julia Johnston, Louisa Mulligan, Yushan Li, Anning Cui, Karim Belkas, Yuxuan Xue, Yuna Um, Amy Yuan, , Christopher A. Ross

The paper screens a kinase inhibitor library in HD iPSC-derived neurons to identify PKC alpha and beta1 inhibition as neuroprotective against mutant huntingtin toxicity.

bioRxiv · Sep 18, 2025 · PreprintNeuroscience