Author

Matthew Rodriguez

Johns Hopkins UniversityORCID 0009-0000-5415-0168Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein design· 1 Research Focus:protein structure prediction· 1 Assay:proteomics· 1

Frequent Co-Authors

Chloe D. Holland· 2 shared Christopher A. RossiD· 2 shared Mali JiangiD· 2 shared Tamara RatovitskiiD· 2 shared Tianze ShiiD· 2 shared Alexey V. Shevelkin· 1 shared Amy Yuan· 1 shared Anning Cui· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersNeuroscience

Chloe D. Holland

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2 papers

Recent·Most cited

NeuroscienceLife Science AlliancePeer-reviewedMar 18, 2026

Huntingtin interactome reveals huntingtin role in regulation of double strand break DNA damage response (DSB/DDR), chromatin remodeling and RNA processing pathways

Tamara Ratovitski, Chloe D. Holland, Robert N. O’Meally…·Christopher A. Ross

The paper identifies HTT interactors involved in DNA damage response, chromatin remodeling, and RNA processing pathways, revealing HTT's role in double strand break repair and its interaction with DNA-PKcs and RNA binding proteins.

2 citations

humanproteomics

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NeurosciencebioRxivPreprintSep 18, 2025

Screening of a kinase inhibitor library in human Huntington disease iPSC derived striatal precursor neurons reveals a neuroprotective effect of PKC alpha and PKC beta1 inhibition

Mali Jiang, Tianze Shi, Ritika Miryala…·Christopher A. Ross

The paper screens a kinase inhibitor library in HD iPSC-derived neurons to identify PKC alpha and beta1 inhibition as neuroprotective against mutant huntingtin toxicity.

DOI 10.1101/2025.09.18.677178

humanbulk RNA-seq

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