MHC restriction is structurally encoded by the T cell receptor germline
Nan Wang, Marta T. Borowska, Kevin M. Jude, Xiaojing Tina Chen, Chunyu Wang, Xinyu Xiang, Liu Daisy Liu, Rong Ma, Anshika Motiani, Steven C. Wilson, Wanlu Liu, K. Christopher García
The paper shows that TCR germline sequences encode MHC restriction, revealing a structural basis for TCR recognition of MHC molecules independent of antigenic peptide.
bioRxiv · Sep 29, 2026 · PreprintImmunology