Chunyu Wang

The paper shows that TCR germline sequences encode MHC restriction, revealing a structural basis for TCR recognition of MHC molecules independent of antigenic peptide.

The paper develops LINC-seq to identify functional TCR-pMHC pairs by clonal expansion and deep mutational scanning, achieving high accuracy in recovering known cognate pairs and resolving co-evolutionary interactions.

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

The paper designs high specificity binders for peptide-MHC-I complexes using deep learning, achieving specific targeting of pMHCs and enabling T-cell activation.