Rong Ma

The paper shows that TCR germline sequences encode MHC restriction, revealing a structural basis for TCR recognition of MHC molecules independent of antigenic peptide.

This study shows CD16a mediates NK cell activation by transducing piconewton forces, integrating biochemical and biophysical signals to enhance ADCC.

The paper develops LINC-seq to identify functional TCR-pMHC pairs by clonal expansion and deep mutational scanning, achieving high accuracy in recovering known cognate pairs and resolving co-evolutionary interactions.