Nan Wang

The paper shows that TCR germline sequences encode MHC restriction, revealing a structural basis for TCR recognition of MHC molecules independent of antigenic peptide.

This paper designs soluble, miniaturized MHC proteins that enable stable expression in E. coli and retain peptide and TCR binding specificity.

This paper introduces ADAPT, a deep learning framework for designing TCRs and antibodies that bind to specific pMHC targets, validated through cryo-EM structures and functional testing.

A de novo four-helix bundle designed with RFdiffusion and ProteinMPNN binds NY-ESO-1/HLA-A*02 at Kd 9.5 nM, with a 2.05 Å crystal structure and peptide-focused docking.

The paper identifies lncRNAs in human germ cells and shows LNC1845 regulates LHX8 through histone modifications during gonadal development.

This study reprograms human fibroblasts into Sertoli cells using NR5A1 and GATA4, showing they resemble primary Sertoli cells and support spermatogonia viability and immune suppression.