Characterization of a gene-trap knockout mouse model of Scn2a encoding voltage-gated sodium channel Nav1.2
Muriel Eaton, Jingliang Zhang, Zhixiong Ma, Anthony C. Park, Emma E Lietzke, Chloé Maricela Romero, Yushuang Liu, Emily Rose Coleman, Xiaoling Chen, Tiange Xiao, Zhuo Huang, William C. Skarnes, Wendy A. Koss, Yang Yang
This paper characterizes a Scn2a gene trap knockout mouse model with reduced Nav1.2 expression, showing behavioral and physiological abnormalities associated with Scn2a deficiency.
bioRxiv · Jun 23, 2020 · PreprintNeuroscience