Tiange Xiao

This study shows that inhibiting the cortical amygdala reduces alcohol intake in dependent mice and restores thalamic connectivity during withdrawal.

This study shows that restoring NaV1.2 expression in adulthood rescues social deficits and improves neuronal signal-to-noise ratio in Scn2a-deficient mice.

This study develops a mouse model of fentanyl self-administration and withdrawal, showing escalation in intake, withdrawal symptoms, and prolonged craving.

This study shows human iPSC-derived microglia detect and reduce hyperexcitability in neurons with the SCN2A-L1342P epilepsy mutation through morphological and calcium changes and reduced sodium channel current density.

This study examines how visual experience affects inter-areal network connectivity in the visual cortex of Fmr1 KO mice, revealing impaired synchronization and synaptic connectivity in FX models.

This study shows that severe NaV1.2 deficiency increases neuronal excitability in adult mice, challenging the current understanding of its role in autism and epilepsy.

This paper characterizes a Scn2a gene trap knockout mouse model with reduced Nav1.2 expression, showing behavioral and physiological abnormalities associated with Scn2a deficiency.