Author

Wendy A. Koss

Purdue University West LafayetteORCID 0000-0002-2980-0672Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3

Frequent Co-Authors

Jingliang ZhangiD· 2 shared Muriel EatoniD· 2 shared Tiange XiaoiD· 2 shared William C. SkarnesiD· 2 shared Xiaoling CheniD· 2 shared Yang YangiD· 2 shared Abigail D. CoxiD· 1 shared Alyssa M. Richards· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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2 shared papersNeuroscience

Jingliang ZhangORCID

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3 papers

Recent·Most cited

Positive allosteric modulator of SERCA pump NDC-1171 attenuates cardiac functional decline in mouse model of Duchenne muscular dystrophy

Niharika Narra, Alyssa M. Richards, Conner C. Earl, Abigail D. Cox, Russell S. Dahl, Wendy A. Koss, Craig J. Goergen

NDC-1171, a SERCA pump modulator, preserves cardiac function in DMD mice but does not improve skeletal muscle function.

Function · Sep 10, 2026Peer-reviewedPharmacology & Toxicology

Restoration of excitation/inhibition balance enhances neuronal signal-to-noise ratio and rescues social deficits in autism-associated Scn2a-deficiency

Jingliang Zhang, Muriel Eaton, Xiaoling Chen, Yuanrui Zhao, Shivam Kant, Brody A. Deming, Kothandaraman Harish, Huynhvi P. Nguyen, Yue Long Shu, Shirong Lai, Jiaxiang Wu, Zhefu Que, Kyle W. Wettschurack, Zaiyang Zhang, Tiange Xiao, , Yang Yang

This study shows that restoring NaV1.2 expression in adulthood rescues social deficits and improves neuronal signal-to-noise ratio in Scn2a-deficient mice.

bioRxiv · Mar 4, 2025 · PreprintNeuroscience

Characterization of a gene-trap knockout mouse model of Scn2a encoding voltage-gated sodium channel Nav1.2

Muriel Eaton, Jingliang Zhang, Zhixiong Ma, Anthony C. Park, Emma E Lietzke, Chloé Maricela Romero, Yushuang Liu, Emily Rose Coleman, Xiaoling Chen, Tiange Xiao, Zhuo Huang, William C. Skarnes, Wendy A. Koss, Yang Yang

This paper characterizes a Scn2a gene trap knockout mouse model with reduced Nav1.2 expression, showing behavioral and physiological abnormalities associated with Scn2a deficiency.

bioRxiv · Jun 23, 2020 · PreprintNeuroscience