Region-specific Brain Targets Drive Circuit Formation and Maturation of Human Retinal Ganglion Cells
Kang-Chieh Huang, Eyad Shihabeddin, Han-Yin Jeng, Qudrat Abdulwahab, Victoria R. Cuevas, Anthony Ho, Claire Young, Melody Hernandez, Justin S. Dhindsa, Mikhail Y. Kochukov, Snigdha Srivastava, Benjamin Russell Arenkiel, Jason S. Meyer, Nicholas M. Tran, Melanie A. Samuel
This paper develops an in vitro model to study human retinal ganglion cell (RGC) connectivity with specific brain regions, showing that cultured RGCs form region-specific synapses with mouse brain targets.
bioRxiv · May 10, 2025 · PreprintNeuroscience