Author

Melanie A. Samuel

Baylor College of MedicineORCID 0000-0002-4804-2491Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Danye JiangiD· 2 shared Nicholas E. AlbrechtiD· 2 shared Viktor AkhanoviD· 2 shared A Paul· 1 shared Akshar J. Trivedi· 1 shared Anthony Ho· 1 shared Arnav Murthy· 1 shared Benjamin Russell ArenkieliD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersNeuroscience

Danye JiangORCID

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Author profile →

4 papers

Recent·Most cited

Overlapping MHC class I/II Epitopes Program cDC1-like Differentiation of Monocyte-Derived Dendritic Cells via mTORC1 Signaling Inhibition

Sharon Bright Amanya, Arnav Murthy, Nalini Bisht, Zaniqua N. Bullock, Keenan Ernste, Jonathan Vazquez‐Perez, W. Liu, Akshar J. Trivedi, Damilola Oyewole-Said, A Paul, Leilani Umokoro, Viktor Akhanov, Melanie A. Samuel, Zhongcheng Shi, Michael Nguyen, , WK Decker

The paper shows that overlapping MHC class I/II epitopes promote cDC1-like differentiation of moDC through mTORC1 inhibition, enhancing type 1 immunity.

bioRxiv · Apr 8, 2026 · PreprintImmunology

Region-specific Brain Targets Drive Circuit Formation and Maturation of Human Retinal Ganglion Cells

Kang-Chieh Huang, Eyad Shihabeddin, Han-Yin Jeng, Qudrat Abdulwahab, Victoria R. Cuevas, Anthony Ho, Claire Young, Melody Hernandez, Justin S. Dhindsa, Mikhail Y. Kochukov, Snigdha Srivastava, Benjamin Russell Arenkiel, Jason S. Meyer, Nicholas M. Tran, Melanie A. Samuel

This paper develops an in vitro model to study human retinal ganglion cell (RGC) connectivity with specific brain regions, showing that cultured RGCs form region-specific synapses with mouse brain targets.

bioRxiv · May 10, 2025 · PreprintNeuroscience

Rapid 3D-STORM imaging of diverse molecular targets in tissue

Nicholas E. Albrecht, Danye Jiang, Viktor Akhanov, Robert J. Hobson, Colenso M. Speer, Michael A. Robichaux, Melanie A. Samuel

RAIN-STORM enables rapid 3D nanoscale imaging of multiple molecular targets in tissue, revealing detailed structures in human samples.

Cell Reports Methods · Jan 1, 2021Peer-reviewedNeuroscience

Progressive myoclonic epilepsy-associated gene Kctd7 regulates retinal neurovascular patterning and function

Jonathan Alevy, Courtney A. Burger, Nicholas E. Albrecht, Danye Jiang, Melanie A. Samuel

This paper identifies Kctd7 as a regulator of retinal vascular patterning and function, showing its role in neuronal regulation of vascular development and its potential involvement in human disease pathogenesis.

Neurochemistry International · Jun 5, 2019Peer-reviewedNeuroscience