Neutrophil Reprogramming Underlie Vasculopathy and Lung Disease in Systemic Sclerosis
Norma Maugeri, Giuseppe Alvise Ramirez, Annalisa Capobianco, Antonella Monno, Erika Arosio, Marco D’Ercole, Marco E. Bianchi, Patrizia Querini Rovere, Florenzo Iannone, Marco Matucci‐Cerinic, Angelo Andrea Manfredi
This study identifies neutrophil reprogramming in systemic sclerosis (SSc) driven by HMGB1+ extracellular vesicles, leading to lung inflammation and fibrosis, and suggests therapeutic targeting of HMGB1.
Cell Death and Disease · Apr 4, 2026Peer-reviewedImmunology