Mitochondrial protein import couples proteostasis failure to mitochondrial permeabilization
Zhiqi Sun, Hauke Holthusen, Sara Berndl, Antonia Behnsen, Sophia J. Schwojer, Giulia Gobbato, Grace Sorensen, Bettina Warscheid, Stephan A. Sieber, F. Ulrich Hartl, Veit Hornung
This study identifies mitochondrial protein import as a pathway linking proteostasis failure to mitochondrial permeabilization, showing that Raptinal impairs protein folding and VBIT4 inhibits this process.
bioRxiv · Sep 6, 2026 · PreprintCell Biology