Bettina Warscheid

This study identifies mitochondrial protein import as a pathway linking proteostasis failure to mitochondrial permeabilization, showing that Raptinal impairs protein folding and VBIT4 inhibits this process.

This study shows that MYC suppresses lysosomal protein degradation in pancreatic ductal adenocarcinoma, promoting immune evasion by altering amino acid availability and immune cell responses.

The paper identifies SDC-3 as an adaptor for condensin IDC recruitment to X chromosomes in C. elegans and shows its role in dosage compensation through loop-extrusion activity.

The paper identifies PEX38 as a novel, essential peroxin in Euglenozoa, evolved from a remnant GET-pathway factor, and highlights its role in peroxisomal membrane protein targeting and potential as a therapeutic target.

This study quantifies the yeast peroxisomal proteome under different metabolic conditions, revealing significant changes in protein abundance related to metabolic functions.

The paper shows TbTim20 is critical for protein import under low membrane potential in trypanosomes lacking mitochondrial DNA.

This study identifies PEX39 as a cytosolic peroxin that facilitates PTS2-protein import by interacting with PEX7 and stabilizing its binding to cargo.

The paper shows NRBP1 and NRBP2 oppositely regulate LINE1 retrotransposition through proteasome-mediated degradation of NRBP1 by NRBP2, with NRBP2's regulatory function evolving later.

This study shows CD20 phosphorylation by PKCδ links it to the RhoA/Rock1 pathway via 14-3-3 and GEF-H1, regulating MT stability and actomyosin contractility in B cells.

This paper identifies TAC53 as a novel component of the Tripartite Attachment Complex (TAC) in Trypanosoma brucei, revealing its tubular architecture and role in mitochondrial DNA segregation.

The paper uses proteomics and lipidomics to show OCIAD1 balances mitochondrial and peroxisomal lipid metabolism by affecting lipid composition and key enzymes.

The paper compares transcriptomics and proteomics data from wild-type and peroxisome-deficient yeast to identify changes in cellular processes due to peroxisome loss.

The paper identifies Mar26 as a determinant in cytochrome bc1 complex assembly, showing it connects assembly intermediates to MICOS to coordinate complex III maturation at crista junctions.

This study shows that TbPam16 and TbPam18 in Trypanosoma brucei regulate maxicircle replication in mitochondria through a novel regulatory circuit involving MaRF11 and proteasomal control.

The paper identifies TbTim15 as an essential subunit of the trypanosome TIM complex, showing it mediates import of both presequence-containing and mitochondrial carrier proteins.

Autoprot provides a Python module for proteomics data analysis, integrating R algorithms and interactive visualization for MS-based experiments processed with MaxQuant.

The paper investigates how cardiac stress regulates Filamin C dimerisation through phosphorylation-modulated interactions with HSPB7, revealing evolutionary conservation of this mechanism.

The paper analyzes protein thiol oxidation in aged yeast and creates a database for cross-species comparison of redoxome data.

This study identifies HPO-11 as a pseudokinase that inhibits nonsense-mediated decay (NMD) to maintain genome stability in C. elegans by preventing R-loop accumulation and DNA damage.

DIMA selects an imputation algorithm based on data characteristics, achieving reliable performance across proteomics datasets with missing values.

The paper provides the first structural characterization of the yeast peroxisomal docking complex Pex14p/Pex17p, revealing its subunit organization and potential role in import pore formation.