Hauke Holthusen

Mitochondrial protein import couples proteostasis failure to mitochondrial permeabilization

This study identifies mitochondrial protein import as a pathway linking proteostasis failure to mitochondrial permeabilization, showing that Raptinal impairs protein folding and VBIT4 inhibits this process.

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

This study shows that proteostatic stress in mitochondria impairs mitoribosome biogenesis and translation, leading to respiratory deficiency and mitochondrial DNA loss.