F. Ulrich Hartl

Aggregate Deep Visual Proteomics reveals selective organization of α-synuclein inclusions

This study uses Aggregate Deep Visual Proteomics to show that α-synuclein inclusions selectively concentrate specific proteins in neurons, revealing their formation mechanisms and potential therapeutic targets.

Q-DOAS: A Proximity Quenching Assay for Real-Time Detection of Early Protein Aggregation Events

Q-DOAS detects early protein aggregation events in real time using a proximity-quenching assay, providing quantitative data for studying neurodegenerative diseases.

Mitochondrial protein import couples proteostasis failure to mitochondrial permeabilization

This study identifies mitochondrial protein import as a pathway linking proteostasis failure to mitochondrial permeabilization, showing that Raptinal impairs protein folding and VBIT4 inhibits this process.

Virus-mediated tau aggregate seeding in a cellular model

This study shows that tau aggregates can be packaged into lentiviral particles and induce tau aggregation in recipient cells, suggesting a potential mechanism linking viral infections to neurodegenerative diseases.

Tryptoline Stereoprobe Elaboration Identifies Inhibitors of the GRPEL1-HSPA9 Chaperone Complex

The paper identifies inhibitors of the GRPEL1-HSPA9 chaperone complex using tryptoline stereoprobes and shows they target non-orthosteric sites.

Mitochondrial proteostatic stress disrupts mitoribosome biogenesis and translation

This study shows that proteostatic stress in mitochondria impairs mitoribosome biogenesis and translation, leading to respiratory deficiency and mitochondrial DNA loss.

Alpha-Synuclein aggregates inhibit ESCRT-III through sequestration and collateral degradation

This study shows that alpha-synuclein fibrils sequester and degrade ESCRT-III proteins, leading to endolysosomal damage and increased alpha-synuclein aggregation.

Hydrophobic tails enable diverse functions of the extracellular chaperone clusterin

This study identifies hydrophobic peptide tails in clusterin as essential for its chaperone function and lipid binding, enabling diverse roles in protein clearance and lipoprotein formation.

Novel proteostasis reporter mouse reveals different effects of cytoplasmic and nuclear aggregates on protein quality control in neurons

The paper develops a mouse model with a proteostasis reporter to study how cytoplasmic and nuclear protein aggregates affect neuronal protein quality control in aging and disease.

Gel-like inclusions of C-terminal fragments of TDP-43 sequester and inhibit proteasomes in neurons

This study identifies TDP-25 inclusions as sequestering proteasomes, leading to proteostasis impairment in ALS/FTD.