A small molecule inhibitor Mirin prevents TOP3A-dependent mtDNA breakage and segregation
Koit Aasumets, Anu Hangas, Cyrielle P. J. Bader, Direnis Erdinc, Sjoerd Wanrooij, Paulina H. Wanrooij, Steffi Goffart, Jaakko Pohjoismäki
Mirin prevents mtDNA breakage and immune response in MGME1-deficient cells through MRE11-independent mechanisms involving TOP3A and mtDNA replication termination.
bioRxiv · Mar 14, 2024 · PreprintMolecular Biology