Author

Koit Aasumets

Umeå UniversityORCID 0000-0002-3405-1741Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 2 Cell Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Assay:DNA methylation· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Assay:whole-genome sequencing· 2 Research Focus:clustering· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Sjoerd WanrooijiD· 3 shared Andreas BerneriD· 2 shared Jaakko PohjoismäkiiD· 2 shared Namrata ChaudhariiD· 2 shared Steffi GoffartiD· 2 shared Alva AbrahamssoniD· 1 shared Anaïs LamyiD· 1 shared Anders DahléniD· 1 shared

Activity by Year

2024-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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3 shared papersMolecular Biology

Sjoerd WanrooijORCID

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4 papers

Recent·Most cited

Dual Recognition Drives Site-Directed G-Quadruplex Stabilization: Exploring Oligonucleotide Design in G4 Ligand-Oligonucleotide Conjugates

Alva Abrahamsson, Sakina Khwaja, Namrata Chaudhari, Steven Vertueux, Andreas Berner, Koit Aasumets, Chandan Kumar, Lotte Stietz, Tom Baladi, Anders Dahlén, Sjoerd Wanrooij, Erik Chorell

This study explores how oligonucleotide design affects G4 ligand-conjugated oligonucleotide binding and stabilization of G-quadruplex structures.

Molecular Therapy — Nucleic Acids · Aug 14, 2026Peer-reviewedMolecular Biology

Redox-dependent dimerization of PolDIP2 and a conserved ApaG-domain motif required for CHCHD2 interaction

Tran Nguyen, Andreas Berner, Kazutoshi Kasho, Anaïs Lamy, Kieran Deane-Alder, Koit Aasumets, Namrata Chaudhari, Cuncun Qiao, Louise Leite Fernandes, Ronnie P.‐A. Berntsson, Sjoerd Wanrooij

This study identifies redox-dependent dimerization of PolDIP2 and a conserved ApaG-domain motif critical for CHCHD2 interaction, revealing structural features governing its mitochondrial function.

bioRxiv · Mar 16, 2026 · PreprintCell Biology

Species-specific variation in mitochondrial genome tandem repeat polymorphisms in hares (Lepus spp., Lagomorpha, Leporidae) provides insight into their evolution

Riikka Tapanainen, Koit Aasumets, Zsófia Fekete, Steffi Goffart, Éric Dufour, Jaakko Pohjoismäki

The paper analyzes mitochondrial tandem repeat variation in hares, finding species-specific differences and suggesting these repeats are selfish genetic elements rather than regulatory.

Gene · Jun 6, 2024Peer-reviewedGenetics

A small molecule inhibitor Mirin prevents TOP3A-dependent mtDNA breakage and segregation

Koit Aasumets, Anu Hangas, Cyrielle P. J. Bader, Direnis Erdinc, Sjoerd Wanrooij, Paulina H. Wanrooij, Steffi Goffart, Jaakko Pohjoismäki

Mirin prevents mtDNA breakage and immune response in MGME1-deficient cells through MRE11-independent mechanisms involving TOP3A and mtDNA replication termination.

bioRxiv · Mar 14, 2024 · PreprintMolecular Biology