Molecular BiologybioRxivPreprint
A small molecule inhibitor Mirin prevents TOP3A-dependent mtDNA breakage and segregation
Koit Aasumets, Anu Hangas, Cyrielle P. J. Bader…·Jaakko Pohjoismäki
Mirin prevents mtDNA breakage and immune response in MGME1-deficient cells through MRE11-independent mechanisms involving TOP3A and mtDNA replication termination.
DOI 10.1101/2024.03.14.585071