Tyler J. Gibson

Ovarian development is driven by early spatiotemporal priming of the coelomic epithelium

This study shows that ovarian cellular diversity arises from spatially organized, transcriptionally heterogeneous coelomic epithelium progenitors in fetal mouse and human ovaries, which are primed toward supporting or steroidogenic identities.

Single cell-scale spatial transcriptome profiling of the adult cycling mouse uterus

This study uses spatial transcriptomics to analyze the adult cycling mouse uterus, identifying cell types and their transcriptional changes across the estrous cycle.

Single-cell-scale spatial transcriptome reveals early regional priming of the developing mouse ovary

This study uses spatial transcriptomics to map ovarian development in mice, identifying a medullary core of pregranulosa cells poised for activation.

Catalytic-dependent and independent functions of the histone acetyltransferase CBP promote pioneer factor-mediated zygotic genome activation

This study shows that CBP, a histone acetyltransferase, has both catalytic and non-catalytic roles in zygotic genome activation, independent of its acetylation function.

Protein-intrinsic properties and context-dependent effects regulate pioneer-factor binding and function

This study shows that pioneer-factor activity depends on chromatin occupancy and is influenced by protein-intrinsic and cell-type-specific factors.

Localization of the pioneer factor GAF to subnuclear foci is driven by DNA binding and required to silence satellite repeat expression

This study shows that the pioneer factor GAF localizes to subnuclear foci through binding to GA-satellite repeats, which is necessary for forming heterochromatin and silencing satellite repeat expression.

Cell-type-specific chromatin occupancy by the pioneer factor Zelda drives key developmental transitions in Drosophila

The paper shows Zelda, a pioneer factor, works with Notch to maintain neuroblasts undifferentiated and reprograms progenitor cells, but its function is limited by repressors and depends on chromatin accessibility and cofactors.

GAF is essential for zygotic genome activation and chromatin accessibility in the early Drosophila embryo

The paper identifies GAF as a maternally encoded factor essential for zygotic genome activation and chromatin accessibility during the maternal-to-zygotic transition in Drosophila.

Establishment of chromatin accessibility by the conserved transcription factor Grainy head is developmentally regulated

This study shows that the pioneer transcription factor Grainy head's chromatin accessibility establishment is temporally regulated during Drosophila development.