Anusha Sarbahi

Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions into amyloid fibrils

This study shows that Ydj1, a heat shock protein 40, prevents amyloid fibril formation by promoting heterotypic phase separation of tau through electrostatic and hydrophobic interactions.

Chaperone-mediated heterotypic phase separation prevents the amyloid formation of the pathological Y145Stop variant of the prion protein

This study shows that Ydj1, an Hsp40, prevents amyloid formation of the Y145Stop prion protein variant through heterotypic phase separation.