Author

Sandeep K. Rai

Boston Children's HospitalORCID 0000-0002-5153-9650Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Sandeep K. Rai2 papers · Indian Institute of Science Education and Research Mohali

Biology Disciplines

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Biochemistry· 1 Biophysics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Organism:human· 1 Assay:long-read sequencing· 1 Approach:microscopy & imaging analysis· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Ryan A. FlynniD· 2 shared Anusha Sarbahi· 1 shared Ashish JoshiiD· 1 shared Dennis K. JeppeseniD· 1 shared Guowei SuiD· 1 shared James N. HigginbothamiD· 1 shared Jeffrey D. EskoiD· 1 shared Jian LiuiD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersBiochemistry

Ryan A. FlynnORCID

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Author profile →

3 papers

Recent·Most cited

Intact and single-molecule analysis of heparan sulfate

Petar Hristov, Pooria Daneshvar Kakhaki, Talia Tzadikario, Sandeep K. Rai, Guowei Su, Paulo H. Olivieri, Jeffrey D. Esko, Jian Liu, Miten Jain, Ryan A. Flynn

This paper introduces HS-nano-seq, a method to analyze heparan sulfate using nanopore sequencing, enabling single-molecule detection of sulfation patterns and structural features.

bioRxiv · Jun 29, 2026 · PreprintBiochemistry

Catch and release of sialoglycoRNAs enables sequencing-based profiling across cellular and extracellular material

Ruiqi Ge, Dennis K. Jeppesen, Sandeep K. Rai, Qin Zhang, James N. Higginbotham, Robert J. Coffey, Ryan A. Flynn

The paper introduces rPAL-seq, a method for profiling sialoglycoRNAs with low RNA input, revealing lineage-associated patterns and secreted glycoRNA profiles.

bioRxiv · Oct 4, 2025 · PreprintMolecular Biology

Chaperone-mediated heterotypic phase separation regulates liquid-to-solid phase transitions into amyloid fibrils

Sandeep K. Rai, Roopali Khanna, Anusha Sarbahi, Ashish Joshi, Samrat Mukhopadhyay

This study shows that Ydj1, a heat shock protein 40, prevents amyloid fibril formation by promoting heterotypic phase separation of tau through electrostatic and hydrophobic interactions.

Science Advances · Jun 6, 2025Peer-reviewedBiophysics