CDK4/6 inhibitors promote PARP1 degradation and act synergistically with PARP inhibitors in non-small cell lung cancer
Carlos M. Roggero, Anwesha B Ghosh, Anvita Devineni, Shihong Ma, Eliot B. Blatt, Ganesh V. Raj, Yi Yin
This study shows CDK4/6 inhibitors promote PARP1 degradation and synergize with PARP inhibitors to kill NSCLC cells by enhancing DNA damage and apoptosis.
Translational Oncology · Dec 10, 2024Peer-reviewedCancer Biology