Author

Eliot B. Blatt

Children's Medical CenterORCID 0000-0002-9515-6547Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

Anvita Devineni· 1 shared Anwesha B Ghosh· 1 shared Carlos M. RoggeroiD· 1 shared Feng CaiiD· 1 shared Ganesh V. RajiD· 1 shared Imani M. WilliamsiD· 1 shared Islam AlshamlehiD· 1 shared Jing ZhangiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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Curved chords = mutual co-authorship

1 shared paperCancer Biology

Anvita Devineni

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

NUDT5 regulates purine metabolism and thiopurine sensitivity by interacting with PPAT

Zheng Wu, Phong T. Nguyen, Varun Sondhi, Run-Wen Yao, Zhifang Lu, Tao Dai, Jui‐Chung Chiang, Feng Cai, Imani M. Williams, Eliot B. Blatt, Zeng‐Fu Shang, Ling Cai, Jing Zhang, Mya D. Moore, Islam Alshamleh, , Ralph J. DeBerardinis

This study identifies NUDT5 as a regulator of purine metabolism and thiopurine sensitivity by interacting with PPAT, independent of its known enzymatic activity.

Science · Nov 6, 2025Peer-reviewedBiochemistry

CDK4/6 inhibitors promote PARP1 degradation and act synergistically with PARP inhibitors in non-small cell lung cancer

Carlos M. Roggero, Anwesha B Ghosh, Anvita Devineni, Shihong Ma, Eliot B. Blatt, Ganesh V. Raj, Yi Yin

This study shows CDK4/6 inhibitors promote PARP1 degradation and synergize with PARP inhibitors to kill NSCLC cells by enhancing DNA damage and apoptosis.

Translational Oncology · Dec 10, 2024Peer-reviewedCancer Biology