Human iPSC Derived Enamel Organoid Guided by Single-Cell Atlas of Human Tooth Development
Ammar Alghadeer, Sesha Hanson-Drury, Devon Duron Ehnes, Yan Ting Zhao, AP Patni, Diana R. O’Day, CH Spurrell, Aishwarya A. Gogate, Ashish Phal, H. Zhang, Arikketh Devi, Yuliang Wang, Lea M. Starita, Dan Doherty, Ian A. Glass, , Hannele Ruohola‐Baker
The paper establishes a single-cell atlas of human tooth development and uses it to guide the in vitro differentiation of ameloblasts from iPSCs, developing a mineralizing enamel organoid system.
bioRxiv · Aug 9, 2022 · PreprintDevelopmental Biology